Cyclin Proteins: Key Regulators Of Cell Cycle Progression And Cancer Development
Cyclin proteins, key regulators of the cell cycle, are synthesized in the cytoplasm through gene expression, regulated by transcription factors and cell cycle checkpoints. They form cyclin-CDK complexes with cyclin-dependent kinases (CDKs), which phosphorylate target proteins to control cell cycle progression. The presence of cyclin proteins varies according to cell cycle stages, ensuring timely cell division. Dysregulated cyclin protein expression can disrupt the cell cycle, potentially leading to uncontrolled growth and proliferation.
